The matchup between Buffalo Bills and Detroit Lions takes place at Ford Field on Thursday November 24 at 5:30 PM. The Sportsbooks have Buffalo Bills as the favorite, with the Moneyline at -441 and the Spread at -9.5. 53% of the Public’s wagers at the Spread have been on Buffalo Bills. The Game Total line is at 54.5.Read further below for the best betting picks from the OddsCrowd community and more important stats and insights. Use the other tabs to see the best odds from the legal US sportsbooks and track your betting picks.