Seahawks vs Cardinals NFL Week 4 TNF Picks
Seahawks vs Cardinals NFL Week 4 TNF Picks
Week 4 of the 2025 NFL season will get underway on Thursday Night Football, as the Arizona Cardinals play host to the Seattle Seahawks in a pivotal matchup in the NFC West. With the Rams losing to the Eagles last week and San Francisco suffering even more injuries, this game certainly presents a chance for both of these teams to make a run at first place in the division. Which team will come out on top and move to 3-1 on the season? Let’s get into our Seahawks vs Cardinals best bets for TNF.
Seahawks vs Cardinals TNF predictions
- Pick #1: Seattle Seahawks ML over Arizona Cardinals (-115) Click Here to Bet
- Pick #2: Under 43.5 Total Points (-110) Click Here to Bet
- Pick #3: Trey Benson anytime touchdown scorer (+110) Click Here to Bet
PICK #1: Seahawks ML over Cardinals (-115)
Heading into the season, there were plenty of questions surrounding what the Seahawks would look like on both sides of the ball. However, through three weeks, it’s clear that head coach Mike Macdonald has already transformed this defense into one of the better units in the league. More importantly, the Seahawks' offensive line has looked much stronger than it was a year ago, which led to very solid outputs from Sam Darnold in the passing game and Kenneth Walker out of the backfield.
Conversely, the Cardinals' offense has looked pretty unimpressive to this point, despite a very weak schedule of opposing defenses. Furthermore, Arizona will now be without running back James Connor, and the Cardinals could struggle to push the ball downfield against Seattle’s strong secondary. We’ll take the Seahawks on the money line.
PICK #2: Under 43.5 (-110)
Regardless of which team wins on Thursday, this game projects to be a close, low-scoring affair. Seattle's defense currently sits at second in opponent points per game and first in the NFL in points per play allowed. This is also one of the best defenses in football in the red zone, which leads us to believe that the Seahawks will be able to limit explosive plays and hold the Cardinals to field goals instead of touchdowns.
On the other side, Arizona’s defense has been better than its offense, with the Cardinals sitting at fifth in points per game allowed and inside the top-10 in yards per rush and yards per pass allowed. Given that this game is being played on a short week and both offenses can’t be entirely trusted, the under is the only way we can look.
PICK #3: Trey Benson anytime touchdown scorer (+110)
With Connor out of the lineup for Arizona, Trey Benson steps into the fold as the top running back in an offense that should lean on the ground game a bit more given how good the Seattle secondary has been. The Florida State product has carried the ball 21 times for 125 yards on the season, and since the Cardinals' wide receivers have struggled to this point, we are getting some inherent value on Benson to find the end zone on Thursday Night Football at plus-money odds.
