Ravens vs Bills NFL Week 1 SNF Picks

NFL Week 1 is rolling, and we’ve already seen some exciting matchups. Now all eyes turn to primetime, where Lamar Jackson and the Baltimore Ravens visit Josh Allen and the Buffalo Bills. Kickoff is set for 8:20 PM ET on NBC with Mike Tirico and Chris Collinsworth on the call for Sunday Night Football. It’s great to have SNF back — and with two legitimate AFC contenders facing off, this one promises fireworks.

Let’s jump into three of our top picks for this marquee matchup.

Ravens vs Bills Week 1 SNF picks

Pick #1 - Bills -1.5 (-110) vs Ravens Click Here to Bet

Pick #2 - Game Total over 50.5 Click Here to Bet

Pick # 3 - Derrick Henry (-145) anytime touchdown scorer Click Here to Bet

Pick #1: Bills -1.5 over Ravens (-110)

There’s not a ton of value in such a tight spread, but in a game like this, a point and a half might be all Buffalo needs.

The Bills are entering their second full season without Stefon Diggs, but the offense has regained its identity. James Cook has emerged as a true feature back, and Josh Allen remains the engine of this team. At wideout, Khalil Shakir and rookie Keon Coleman have stepped up as reliable contributors, while veteran Josh Palmer was brought in during the offseason to provide depth. Tight end Dalton Kincaid is finally healthy and could be in for a breakout year.

On defense, Buffalo made some big changes. With Von Miller gone, they added Joey Bosa from the Chargers, a move they hope reignites Bosa’s career and adds punch to the pass rush.

Baltimore, of course, is no pushover. They’re coming off an AFC Championship loss to Kansas City and return one of the league’s most dangerous offenses. The run game, led by Lamar Jackson and Derrick Henry, is elite, with them combining for 20 rushing touchdowns last year. Jackson also took a big leap as a passer in 2024, throwing 41 touchdown passes.

That said, the Ravens have some defensive questions, especially with a few new pieces in the secondary. Special teams could also play a role as they’re breaking in rookie kicker Tyler Loop, and in a game this close, one missed kick could swing things. In a coin-flip game, we’re leaning on Buffalo to cover the small spread. Give us the Bills -1.5 at home, backed by a raucous Bills Mafia crowd.

Pick #2: Game total over 50.5 (-110)

When Lamar Jackson and Josh Allen share a field, points tend to follow — and this matchup looks like another shootout in the making.

The Ravens offense has continued to evolve under coordinator Todd Monken. With Derrick Henry entering his second year in Baltimore, his role is firmly established. That’s opened up the playbook for Lamar, especially in play-action and RPO looks. On the outside, Zay Flowers and Rashod Bateman (who had nine touchdowns last year) bring real speed and big-play ability.

Buffalo, meanwhile, has always played an aggressive brand of football under Allen. They’re not afraid to push the ball downfield and let their QB make plays with his arm and legs. While their defense is solid, it’s not infallible — and Week 1 is rarely when defenses look their sharpest.

The total is 50.5, which feels about right, but we’re leaning Over. Barring any unexpected weather issues in Buffalo (and early forecasts look clear), this one has the makings of a 31–28 or 27–24 kind of game.

Pick #3: Derrick Henry Anytime Touchdown (-145)

It’s not a flashy bet, but it’s a reliable one. Derrick Henry remains Baltimore’s go-to option in the red zone — and that won’t change heading into Year 2.

Henry found the end zone 16 times last season, and even though he’s entering the later stages of his career, he’s still one of the league’s best short-yardage backs. The Ravens use him exactly how they should: to grind out yards inside the 10 and to keep the offense on schedule in tight spots.

With Lamar’s dual-threat ability forcing defenses to stay honest, Henry often sees cleaner looks near the goal line than he ever did in Tennessee. Add in a strong Ravens offensive line that can dominate in run-blocking situations, and the opportunities will be there. In what we expect to be a high-scoring game with multiple trips to the red zone, Henry’s number is almost guaranteed to be called. At -145, the payout isn’t huge, but it’s one of the safest anytime TD props on the board this week.