NFL Week 6 Sunday picks

Week 6 of the 2024 NFL campaign kicked off with the San Francisco 49ers’ defeating the NFC West rival Seattle Seahawks on Thursday Night Football. Now it’s time to turn our attention toward Sunday, and an intriguing schedule is on offer. It includes another London Series game between the Jacksonville Jaguars and Buffalo Bills while the afternoon lineup features the Tampa Bay Buccaneers visiting the New Orleans Saints and the Baltimore Ravens hosting the Washington Commanders.

Here are our best bets for Week 6 of the NFL season: 

NFL Week 6 Predictions 

Houston Texans -6.5 over New England Patriots (-115) 

Arizona Cardinals +5.5 over Green Bay Packers (-114) 

Denver Broncos +3 over Los Angeles Chargers (-115) 

PICK #1: Texans -6.5 over Patriots (-105) 

The New England Patriots are, without a doubt, one of the worst teams in football. They opened with a surprising victory at the Cincinnati Bengals, but that has been followed by a four-game losing streak. The Patriots are 0-2 at home after losing to a struggling Miami Dolphins squad via a 15-10 decision last weekend. It was another anemic performance by the offense, which produced just 16 points in Week 3 and Week 4. The result is a move to No. 3 overall pick Drake Maye as the starting quarterback, replacing Jacoby Brissett. In one garbage-time appearance against the Jets this season, Maye completed four of eight pass attempts for 22 yards while getting sacked twice.

Unfortunately for the Patriots, things may get worse before they get better, regardless of who is under center. After all, Houston is an extremely formidable foe. The Texans are 4-1, and their only loss has come from the undefeated Minnesota Vikings. CJ Stroud has already thrown for 1385 yards and seven touchdowns. There is no reason to think that New England will come close to keeping up with Stroud and company. 

PICK #2: Cardinals +5.5 over Packers (-114)

The Cardinals went into San Francisco in Week 5 and beat the 49ers 24-23, an especially impressive result given how the Niners looked on Thursday night at Seattle. Although Arizona is still a modest 2-3, its road performances have been encouraging as head coach Jonathan Gannon’s team prepares to visit Green Bay. The Cards’ season opener came in Buffalo, where they dropped a 34-28 thriller after finding themselves inside Buffalo’s 30-yard line in the final minute with an opportunity to win the game. 

Meanwhile, the Packers (3-2 overall) have been nothing special at Lambeau Field (1-1). They lost to Minnesota and posted an underwhelming 16-10 victory over the Indianapolis Colts. It does not help that Green Bay has a whole host of starters listed as questionable, including cornerback Jaire Alexander and receiver Christian Watson. Look for Kyler Murray and the Cardinals to cover 5.5 points.

PICK #3: Broncos +3 over Chargers (-115) 

This is an AFC West showdown, and we have seen so often in the NFL that division rivalries are often more competitive than expected. This one should be close, as the Chargers are small -3 favorites. Still, the Broncos should be able to cover a field goal, if not even win outright. Head coach Sean Payton’s squad has won three in a row after starting 0-2. Rookie QB Bo Nix has done a nice job managing games – which is all a QB has to do when he is supported by a defense like Denver’s. The Broncos have surrendered just 47 points over their last four contests and rank second in opponents’ passing yards per attempt for the season.

This Los Angeles outfit is far from great. Its only wins this year have come at the expense of the Las Vegas Raiders and Carolina Panthers. With home-field advantage, count on Denver covering and perhaps even winning outright.