NFL Week 4 Sunday Best Betting Picks
NFL Week 4 Sunday Picks
Week 4 of the 2025 NFL regular season began with a tense Thursday Night Football showdown in the NFC West, won by Seattle 23-20 on a last-second field goal at Arizona. Now it’s time to look ahead toward a jam-packed Sunday slate. The lineup includes Eagles vs. Buccaneers, Vikings vs. Steelers, Colts vs. Rams and Ravens vs. Chiefs, in addition to a great Sunday Night Football matchup between the Packers and Cowboys. Here are our best bets for Sunday’s Week 4 schedule.
NFL Week 4 Predictions
- Pick #1: Los Angeles Chargers -6 (-110) vs. New York Giants Click Here to Bet
- Pick #2: Philadelphia Eagles vs. Tampa Bay Buccaneers Over 43.5 (-118) Click Here to Bet
- Pick #3: Jacksonville Jaguars vs. San Francisco 49ers Under 47.5 (-115) Click Here to Bet
PICK #1: Chargers -6 vs. Giants (-110)
Russell Wilson is out; Jaxson Dart is in. The Giants have made their move at quarterback, going with the rookie instead of the veteran. With a lowly New Orleans outfit on the horizon in Week 5, the timing is somewhat curious given the fact that Dart’s first NFL start will now come against one of the best defenses in the league. The Chargers are No. 9 in both run and pass defense, No. 2 in yards per pass attempt allowed and No. 4 in scoring defense. Dart enjoyed some success during the preseason, but a matchup with an undefeated Los Angeles squad in Week 4 of the regular season is an entirely different beast.
The Bolts’ offense has been solid – and “solid” should be more than enough to handle the 0-3 Giants with ease. Justin Herbert has a 6-to-1 touchdown-to-interception ratio, and his team has not yet scored fewer than 20 points in any contest.
PICK #2: Eagles vs. Buccaneers Over 43.5 (-118)
This is, without question, a potential NFC Championship preview. With the Eagles looking better on offense than defense, a relatively high-scoring affair can be expected, which would be nothing out of the ordinary when these two teams tangle. Nine of the last 11 head-to-head matchups have produced at least 44 points, including last year’s 33-16 victory for the Buccaneers.
More of the same should be in store for Sunday. Philadelphia is banged up defensively, as linebackers Nolan Smith Jr. and Nakobe Dean are out. Fellow LBs Zack Baun and Jihaad Campbell are questionable, as is cornerback Adoree’ Jackson. Tampa Bay quarterback Baker Mayfield also comes in with a questionable tag, but there is no doubt that he is playing. Mayfield’s connection with rookie receiver Emeka Egbuka has already impressed, plus RB Bucky Irving should be able to do some damage against a Philly defense that is giving up 133.3 rushing yards per game and 5.7 yards per attempt.
PICK #3: Jaguars vs. 49ers Under 47.5 (-115)
San Francisco has a lot of question marks on the offensive side of the ball heading into its Week 4 matchup with Jacksonville. In fact, pretty much the only thing to like about the 49ers’ offense these days is Christian McCaffrey. Tight end George Kittle and receiver Brandon Aiyuk are out, the line is banged up, and quarterbacks Brock Purdy and Mac Jones are questionable. Third-string QB Kurtis Rourke is inactive, so the Niners would actually have to consult the practice squad if Purdy and Jones are unavailable. Even if one of those guys can take the field, the offensive situation inspires very little confidence. Moreover, the Jaguars’ run defense has been stout so far this season.
The Jags boast a 2-1 record thanks to a defense that has been stopping the run and forcing turnovers. Offensively, however, they have been scuffling. Trevor Lawrence continues to underwhelm, as he has as many interceptions as touchdown passes (four apiece). No. 2 overall pick Travis Hunter has not yet done anything from the receiver spot (10 catches for 76 yards).
