NFL Week 15 Sunday Best Picks

Week 15 of the 2025 NFL campaign kicked off with a Thursday Night Football showdown between Atlanta and Tampa Bay. Now it’s time to look ahead toward a jam-packed Sunday slate. We have reached the point in the season where there are no more byes, so a massive 14-game Sunday slate is in the cards. It includes Ravens vs. Bengals, Chargers vs. Chiefs, Bills vs. Patriots, Packers vs. Broncos and Lions vs. Rams. Needless to say, this could be the best slate of the season. With that in mind, let’s break down our NFL best bets for Week 15.

NFL Week 15 Predictions 

Pick #1: Arizona Cardinals vs. Houston Texans Under 42.5 (-108) Click Here to Bet

Pick #2: Green Bay Packers vs. Denver Broncos Under 42.5 (-110) Click Here to Bet

Pick #3: Carolina Panthers -2.5 over New Orleans Saints (-115) Click Here to Bet

PICK #1: Cardinals vs. Texans Under 42.5 (-108) Click Here to Bet

The Texans’ defense is flat-out scary. They are No. 1 in the entire league in total defense, No. 1 in scoring defense, No. 4 against the pass and No. 5 against the run. Houston has held four consecutive opponents to fewer than 20 points, including Buffalo, Indianapolis and Kansas City. Head coach DeMeco Ryans’ team has produced 36 sacks and has forced 22 turnovers, the latter number good for fourth-best in the NFL. Will Anderson Jr., Danielle Hunter and the rest of the Texans’ pass rush should have their way with a mediocre Cardinals offensive line. Arizona quarterback Jacoby Brissett has been decent in place of Kyler Murray, but the veteran does not necessarily bring a dynamic element to the offense. As for Houston’s offense, it is also solid but unspectacular. Count on defense dominating the day in this matchup. The under is 4-0 in the Texans’ last four games and 2-0 in the last two head-to-head meetings.

PICK #2: Packers vs. Broncos Under 42.5 (-110) Click Here to Bet

Denver is currently the top seed in the AFC and it is largely due to the defensive side of the ball. Head coach Sean Payton’s squad is No. 3 in the NFL in total defense, No. 4 in scoring defense (18.1 ppg allowed), No. 2 against the run and No. 1 in yards per carry allowed (3.7). Four of the Broncos’ last five opponents have been limited to fewer than 20 points. Cornerback Pat Surtain II won NFL Defensive Player of the Year in 2024, and he is back after being sidelined for a month by a pectoral injury. Denver is solid yet unspectacular offensively, but that’s all Bo Nix and company have to be when they are being supported by such a strong defense. The Broncos probably won’t score a ton this weekend because the Packers’ defense is also outstanding. Newcomer Micah Parsons has been every bit as good as advertised and a big reason why five of Green Bay’s last six opponents have scored no more than 21 points.

PICK #3: Panthers -2.5 over Saints (-115) Click Here to Bet

This is pretty much an ideal spot for the Panthers. They are coming off a bye and facing an opponent that pocketed its biggest win of the season last weekend. The Saints – for the time being – are overrated by the market after upsetting Tampa Bay in Week 14. That was a nice victory, but the Bucs have been a shadow of their former selves during the second half of this 2025 campaign (1-4 record since a Week 9 bye). New Orleans at least gets to play this contest at home, but what kind of advantage does the Caesars Superdome provide these days? Head coach Kellen Moore’s crew is 1-5 at home compared to 2-5 on the road this season. Meanwhile, Carolina improved to 6-3 in its last nine contests after knocking off the high-powered Rams 31-28 in Week 13.