NFL Week 13 Sunday Best Picks 

The upcoming Sunday slate of NFL action is a little less robust than normal since games are more spread out across Thanksgiving week. Nonetheless, there are plenty of betting opportunities. An 11-game lineup includes Texans vs. Colts, Rams vs. Panthers, Bills vs. Steelers and Broncos vs. Commanders on Sunday Night Football. Let’s get into our NFL Week 13 best bets for Sunday’s matchups.

NFL Week 13 Sunday Predictions 

Pick #1: Houston Texans +4.5 over Indianapolis Colts (-110) Click Here to Bet

Pick #2: Miami Dolphins -5.5 over New Orleans Saints (-115) Click Here to Bet

Pick #3: Atlanta Falcons vs. New York Jets Under 40 (-110) Click Here to Bet

PICK #1: Texans +4.5 over Colts (-110) Click Here to Bet

Once 0-3, Houston is 6-2 in its last eight games to get back in the AFC South discussion. Matchups in this division – at least when the two teams involved are at least somewhat even on paper, as is the case here – are often low-scoring slogs that tend to be decided by nothing more than a field goal. This one feels like no exception. 

Although the Colts’ offense has been formidable at times in 2025, not even Jonathan Taylor is likely to solve this ferocious Texans defense. Houston absolutely abused Buffalo quarterback Josh Allen last Thursday night, picking him off twice and sacking him eight times en route to a 23-19 victory. The Texans even held the Bills to 4.9 yards per play. 

Houston is No. 5 in the NFL against the run, so it should be able to contain Taylor while also hounding a mistake-prone Daniel Jones with its dominant pass rush. On the other side of the ball, CJ Stroud has been in the league’s concussion protocol for several weeks, but is trending toward playing on Sunday. Even if they have to go with Davis Mills again, though, the Texans should be able to cover if not even win outright.

PICK #2: Dolphins -5.5 over Saints (-115) Click Here to Bet

The 2-9 Saints may not have the worst record, but they might be the worst team in the entire NFL. They are just awful, and they really should not have two wins. One came against a Giants team that committed a ridiculous five turnovers, and the other was at the expense of the same version of Bryce Young that showed up on Monday night in San Francisco. 

New Orleans’ offense was anemic with Spencer Rattler under center, and it is the same with rookie Tyler Shough running the show. Meanwhile, Miami is on a two-game winning streak and has won three of its last four contests. Head coach Mike McDaniel’s team is coming off a bye, too, so this is a fantastic spot for the home side to take advantage of a terrible opponent.

PICK #3: Falcons vs. Jets Under 40 (-110) Click Here to Bet

Neither offense inspires any confidence regardless of who is playing quarterback. The Jets were inept when it was Justin Fields; they have been the same with Tyrod Taylor. Now the 36-year-old has to face a blitz-heavy Atlanta defense that ranks third in the NFL with 39 sacks. 

New York receiver Garrett Wilson missed last weekend's 23-10 loss to the Ravens with a knee injury and is likely to miss several more weeks. For the Falcons, Michael Penix Jr. is out for the season, which means Kirk Cousins somehow finds himself back in the QB1 position in Atlanta. Cousins is virtually immobile in the latter stages of his career, which is a big problem when the offensive line in front of him is in shambles due to injuries. It does hot help that Drake London (knee) missed Week 12 and is questionable for Sunday.