NFL Week 10 Touchdown Scorer Best Bets

Week 10 of the NFL season is here and we’re hitting that point in the year where teams’ identities are clear. We know which defenses are falling apart, which offenses are humming and which players are becoming must-bet touchdown targets. The middle of the season is when usage patterns stabilize, injuries reshape matchups and oddsmakers occasionally leave soft spots to exploit.

After diving into the numbers and recent trends, we’ve lined up three touchdown scorer bets that combine strong matchups with real value. Let’s get into our favorite touchdown picks for Week 10 after going one for three last week for a small profit thanks to Colston Loveland at +300.

NFL Week 10 Touchdown Scorer Predictions 

Pick #1: Kyren Williams (LAR) Anytime Touchdown Scorer (+100) Click Here to Bet

Pick #2: Darius Slayton (CHI) Anytime Touchdown Scorer (+230) Click Here to Bet

Pick #3: James Cook (BUF) First Touchdown Scorer (+425) Click Here to Bet

Pick #1: Kyren Williams (LAR) Anytime Touchdown Scorer (+100) Click Here to Bet

Kyren Williams has not had quite the success in the red zone this season as we have become accustomed to seeing previously in his career. However, he still has six touchdowns in nine games this year and this matchup sets up perfectly for him to find the end zone again.

The 49ers have been shaky against the run since linebacker Fred Warner went down, giving up chunk plays and struggling with missed tackles. Plus, the 49ers have been hit with the injury bug, once again losing defensive lineman Mykel Williams to a torn ACL.

Williams already torched this defense once back in Week 5, scoring twice through the air. Sean McVay loves scheming him into open space on screens and swing passes and with the 49ers’ front seven missing its anchor, there should be plenty of room for Williams to operate.

At even money, you’re getting one of the most involved backs in football against a defense that’s leaking production on the ground. This one feels like a high-floor, high-upside play.

Pick #2: Darius Slayton (NYG) Anytime Touchdown Scorer (+230) Click Here to Bet

It’s been a rough season for the Giants, sitting at 2-7 and dealing with multiple injuries to their best offensive players in Malik Nabers and Cam Skattebo. Rookie quarterback Jaxson Dart is down to Wan’Dale Robinson and Darius Slayton as his top two playmakers on offense. Slayton is the deep threat in an offense that’s been desperate for explosive moments, and this week’s matchup against the Bears secondary could finally deliver one.

Chicago’s defensive backfield is banged up and has given up splash plays all year. There is no Jaylon Johnson or Kyler Gordon in this matchup, as both are on IR. The Bears are coming off a game in which they allowed 470 receiving yards and four touchdowns to the Cincinnati Bengals.

If Dart can buy a little time in the pocket or extend a play, Slayton has the speed to burn this group downfield. At +230, he’s the perfect blend of value and opportunity in a game where New York may need to take some shots to stay competitive.

Pick #3: James Cook (BUF) First Touchdown Scorer (+425) Click Here to Bet

James Cook has been in a touchdown-scoring groove since last season, and this week he gets a juicy matchup against a Dolphins defense that’s been trending in the wrong direction. Miami just shipped out edge rusher Jalen Phillips and their front seven was already vulnerable to the running game. In the first matchup against the Dolphins this season, Cook saw 19 carries for 108 yards and a touchdown.

Buffalo’s offense has leaned on Cook early in games, and he gets the high-leverage touches near the end zone – ranking 7th in the NFL in red-zone touches. The Dolphins have allowed early scoring drives all season, and Cook’s dual-threat ability gives him multiple ways to punch in the first score – whether it’s a quick dump-off or a burst up the middle.

At +425, this line offers great value for a player that is often heavily involved right out of the gate.