NFL Preseason 2025 Week 2 Picks

The 2025 NFL regular season is less than a month away and every team in the league has at least one preseason game in the books. Now we're in Week 2, when all 32 squads will once again take the field. There are two games on Friday, 11 on Saturday, two on Sunday and finally one on Monday. Yes, it's an embarrassment of riches for football fans. No matter that the games aren't meaningful, we have four straight days of football, just like we did in Week 1. Here are our NFL best bets for the Week 2 preseason slate.

Confirmed Week 2 Matchups & Scheduling

As confirmed by NFL.com and official coverage:

Friday, August 15

7:00 p.m. ET — Tennessee Titans @ Atlanta Falcons (NFL Network, NFL+)

10:00 p.m. ET — Kansas City Chiefs @ Seattle Seahawks (NFL Network, NFL+) 

Saturday, August 16

1:00 p.m. ET — Miami Dolphins @ Detroit Lions (Local TV, NFL+)

1:00 p.m. ET — Green Bay Packers @ Indianapolis Colts (Local TV, NFL+)

1:00 p.m. ET — New England Patriots @ Minnesota Vikings (Local TV, NFL+)

1:00 p.m. ET — Cleveland Browns @ Philadelphia Eagles (NFL Network, NFL+)

1:00 p.m. ET — Carolina Panthers @ Houston Texans (Local TV, NFL+)

4:00 p.m. ET — San Francisco 49ers @ Las Vegas Raiders (Local TV, NFL+)

7:00 p.m. ET — Baltimore Ravens @ Dallas Cowboys (Local TV, NFL+)

7:00 p.m. ET — Los Angeles Chargers @ Los Angeles Rams (Local TV, NFL+)

7:00 p.m. ET — New York Jets (away) @ New York Giants (NFL Network, NFL+)

7:00 p.m. ET — Tampa Bay Buccaneers @ Pittsburgh Steelers (CBS)

9:30 p.m. ET — Arizona Cardinals @ Denver Broncos (NFL Network, NFL+)

Sunday, August 17

1:00 p.m. ET — Jacksonville Jaguars @ New Orleans Saints (NFL Network, NFL+)

8:00 p.m. ET — Buffalo Bills @ Chicago Bears (FOX)

Monday, August 18

8:00 p.m. ET — Cincinnati Bengals @ Washington Commanders (ESPN)

NFL Preseason Week 2 Predictions 

Pick #1: Atlanta Falcons +4.5 over Tennessee Titans (-110) Click Here to Bet

Pick #2: Baltimore Ravens -2.5 over Dallas Cowboys (-112) Click Here to Bet

Pick #3: Buffalo Bills vs. Chicago Bears Over 39.5 (-105) Click Here to Bet

PICK #1: Falcons +4.5 over Titans (-110)

You can rarely feel good about giving more than a field goal in any preseason game; Friday's contest in Atlanta between the Falcons and Titans is no exception. Tennessee (3-14) tied two other teams for the worst record in football last year and it looked every bit like a rock-bottom club in its 2025 preseason opener. The visitors lost to the Tampa Bay Buccaneers 29-7, managing nothing more than a Tony Pollard touchdown run in the second quarter. Cam Ward, the No. 1 overall pick, completed five of eight attempts for 67 yards with no touchdowns or interceptions.

The Falcons fell at home 17-10 to the Detroit Lions, but Easton Stick looked good under center to the tune of 147 yards and a touchdown on 15-for-18 passing. Tennessee is favored because it is expected to play some of its starters, but even its first string might not be overly superior to Atlanta's backups.

PICK #2: Ravens -1.5 over Cowboys (-112)

No franchise has a more impressive recent history of preseason success than Baltimore. It won an unbelievable 24 such games in a row before finally losing to the Washington Commanders 29-28 in Week 2 of the 2023 campaign. The Ravens compiled a 1-2 record in each of the past two years, but they were back to their winning ways in Week 1 – taking care of the visiting Indianapolis Colts 24-16. Cooper Rush didn't do much, but he is a proven quarterback who should be especially motivated to face his former team.

Dallas opened with a 31-21 road setback against the Los Angeles Rams. The Cowboys are generally a traveling circus and this offseason has done nothing to change that assessment, with star edge rusher Micah Parsons having already demanded a trade. Baltimore should probably be a slightly bigger favorite in this matchup.

PICK #3: Bills vs. Bears Over 39.5 (-105)

The Bears produced one of two ties in Week 1 of the preseason, and – by preseason standards – it was a shootout against the Miami Dolphins. They played to a 24-24 draw in what was a thoroughly unspectacular defensive performance by Chicago, even though Tua Tagovailoa stuck around for just one series and left with the score still at 0-0. On the bright side for head coach Ben Johnson's squad, it has a pair of serviceable backups behind Caleb Williams. Both Tyson Bagent and Case Keenum know what they are doing out there and they combined for three touchdowns through the air last week.

Meanwhile, Buffalo got torched by a trio of New York Giants quarterbacks en route to a 34-24 loss. Jaxson Dart, Tommy DeVito and Jameis Winston combined to go 29-for-44 with 291 and all three signal-callers tossed a touchdown pass. For the Bills, Mitch Trubisky and Mike White combined to go 17-for-26 with 250 yards and three TDs. Expect additional offensive success on Sunday night.