October 4, 2026 5:00 PM
Highmark Stadium (Outdoors), Orchard Park, NY
New England Patriots
Money: 77% Public: 52%
W: 1 L: 2
L5: L W L L W L5 ATS: L W W L W
Spread
+6.5
-104
Moneyline
+270
Game Total
u47.5
-105
at
Buffalo Bills
Money: 22% Public: 47%
W: 3
L5: W W W W W L5 ATS: L W W W L
Spread
-7
-105
Moneyline
-312
Game Total
o48.5
-105
Game Preview
Best Odds
Enter Picks
Find the Best Odds for the New England Patriots vs Buffalo Bills matchup at Highmark Stadium on Sunday October 4 2026, 1:00 PM. See a comprehensive Odds Comparison of the full NFL Schedule.

Odds Comparison

Full Game
Bets
Money
Sign up bonus
Moneyline
Moneyline
Patriots
Bills
Bets
15%
84%
Money
10%
89%
Spread
Spread
Patriots
Bills
Bets
52%
47%
Money
77%
22%
Total
Total
Over
Under
Bets
53%
46%
Money
83%
16%
Bonuses
See all

FanDuel

$350 Bonus

Sleeper

$100 Bonus

Dabble

$10 Bonus

Novig

$25 Bonus

Kalshi

$25 Bonus

PolyMarket US

$50 Bonus
18+ Only. Restrictions and eligibility requirements apply. Not available in all jurisdictions. Trading is risky. 100% loss can occur. See polymarket.com/tos for more information. The Polymarket US App serves as an independent software provider and affiliate of Polymarket US and Polymarket Clearing, the CFTC-regulated exchange and clearing organization.